One Health and the Challenge of Antifungal Resistance

4 & 5 April 2024

Draft programme

Thursday 4 April 2024

09:30 Arrival, registration and refreshments

Session 1: One health and antifungal resistance

10:00 Welcome by Neil Brown and Alessandra da Silva Dantas
10:10 The clinical relevance and impacts of antifungal resistance, Andy Borman, UKHSA-MRL
10:30 Antifungal resistance in agricultural environments, Neil Paveley, ADAS
10:50 Antimicrobial use and resistance in plant health: a One Health perspective, Marie Verhaegen, Food and Agriculture Organization of the United Nations (FAO), Italy  
11:10 Refreshments and posters

Session 2: Impacts and surveillance

11:40 The challenge of antifungal drug resistance in Candida auris, Johanna Rhodes, Radboudumc, NL
12:00 Understanding the eco-evolutionary drivers of emerging resistance in Aspergillus fumigatus, Matthew Fisher, Imperial College London
12:20 Water-based early warning for community antimicrobials usage and  antimicrobial resistance: focus on antifungal agent, Barbara Kasprzyk-Hordern, University of Bath
12:40 FungiDB: An integrated functional genomics resource for fungal and oomycete species, Evelina Basenko, FungiDB   
13:00 Lunch and posters

Session 3: Mechanisms and drivers of resistance

14:00 Population heterogeneity as a driver of antifungal resistance in Candida species, Alessandra Da Silva Dantas, Newcastle University
14:20 How may future soils encourage emergence of aggressive toxigenic antifungal-resistant pathogens? Neil Brown, University of Bath
14:40 Fungal diseases in a changing world, Norman van Rhijn, University of Manchester
15:00 Predicting resistance through experimental evolution of a plant pathogen, Nichola Hawkins, NIAB
15:20 Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive the rapid evolution of antifungal resistance, Michael Bottery, University of Manchester
15:40 Refreshments and posters
16:10 Cryptococcus cell surface modifications in antifungal resistanceLiliane Mukaremera, University of Exeter
16:30 Candida glabrata - a powerhouse of resistance, Jane Usher, University of Exeter
16:50 Do we need to be concerned about the dual-use of DHODH inhibitors in the clinic and for crop protection? Mike Bromley, University of Manchester
17:10 Interspecific hybridisation as a new evolutionary fungicide resistance mechanism in fungal pathogens, Fran Lopez-Ruiz Curtin University, Western Australia
17:30 Summary and end of day 1
17:40 Break
19:00 Drinks reception and dinner at the Roman Baths (pre-booked ticket)

Friday 5 April 2024

09:00 Arrival, registration and refreshments

Session 4: Mitigation

09:30 Novel therapeutic targets and approachesCarol Munro, University of Aberdeen
09:50 Will the new generation of azole antifungal inhalers in clinical development solve the problem of fungal asthma? David Denning, University of Manchester 
10:10 Bridging the gap: The Australian Fungicide Resistance Extension Networks (AFREN) One Health approach to managing fungicide resistance in the Australian grains industry, Anna-Sheree Krige, Curtin University, Western Australia
10:30 A global comparison of fungicide recommendations with special reference to resistance, Phil Taylor, CABI
10:50 Refreshments and posters
11:20 Newsnight style panel discussion
Sarah Gurr, University of Exeter(Agricultural perspective)

Kevin Doughty, Bayer,(AgChem Industry perspective)

Mike Bromley, University of Manchester (Clinical perspective)
12:45 Summary and end of conference