Dr. Claudia Schneider PhD

Royal Society University Research Fellow

Research Focus

Essential roles of endoribonucleases in multiple aspects of eukaryotic gene expression

Scientific Activities

Dr. Schneider her research combines bioinformatics, genetic, molecular biology and biochemical approaches in human cells, budding yeast and model pathogenic fungi to understand the underlying mechanisms of essential RNA processing and quality control pathways. These comparative approaches show high promise to identify fungal-specific factors, especially in ribosome biogenesis, which can be explored as targets for the development of new anti-fungal drugs with wide applications in healthcare and agriculture.

Significant Publications

Wells, G. R., Weichmann, F., Colvin, D., Sloan, K. E., Kudla, G., Tollervey, D., Watkins, N. J. and Schneider, C. (2016) The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Nucleic Acids Res. 44(11):5399-409. doi: 10.1093/nar/gkw213.

Sloan, K. E., Bohnsack, M. T., Schneider, C. and Watkins, N. J. (2014) The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA. RNA. 20(4):540-50.

Schneider, C., Kudla, G., Wlotzka, W., Tuck, A. and Tollervey, D. (2012) Transcriptome-wide Analysis of Exosome Targets. Mol. Cell 48(3):422-33.

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Collaborators