Molecular cell biology of stress reponses in Saccharomyces cerevisiae
Martin Schröder is a Lecturer in the Department of Biosciences at Durham University. His research interests focus on the cell biology of stress responses in the genetic model organism Saccharomyces cerevisiae.
A major focus area of the group is to study how eukaryotic cells respond to endoplasmic reticulum stress caused by the accumulation of unfolded proteins in the endoplasmic reticulum, where his group studies the function of the endoplasmic reticulum stress sensor Ire1.
Research into the molecular basis of how endoplasmic reticulum stress signalling pathway intersect with other stress signalling pathways, such as the cell wall integrity or salt tolerance stress signalling pathways is also ongoing.
Other research addresses how yeasts cells choose appropriate responses to nitrogen starvation and how perturbation of metal ion homeostasis can be exploit to develop antifungal agents.
N. Strudwick, M. Brown, V. M. Parmar, M. Schröder, Mol. Cell. Biol. 30 (2010) 5514-5530: Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.
M. Skipsey, G. Hack, T. A, hooper, M. C. Shankey, L. P. Conway, M. Schröder, D. R. W. Hodgson, Nucleosides Nucleotides Nucl. Acids 32 (2013) 670-681: 5'-Deoxy-5'-hydrazinylguanosine as an inityiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs.
Department of Biosciences
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