MRC Research Fellow
Aspergillus fumigatus sulphur metabolism as target to fight fungal virulence
Jorge Amich is a MRC Research Fellow at the Manchester Fungal Infection Group, which performs world-class basic and translational research in fungal pathogenesis.
His research focuses on sulphur metabolism of the human fungal pathogen Aspergillus fumigatus. This core metabolic pathway is essential for fungal viability and therefore has the potential to be targeted for development of novel antifungal therapies. In particular, Jorge investigates the validity of targeting methionine synthase for drug development, the in vivo status and transcriptional regulation of sulphur metabolism and the importance of host derived H2S for fungal pathogenicity.
Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more? Amich J, Bignell E. Curr Opin Microbiol. 2016 Aug;32:151-8.
Exploration of Sulfur Assimilation of Aspergillus fumigatus Reveals Biosynthesis of Sulfur-Containing Amino Acids as a Virulence Determinant. Amich J, Dümig M, O'Keeffe G, Binder J, Doyle S, Beilhack A, Krappmann S. Infect Immun. 2016 Mar 24;84(4):917-29.
Regulation of Sulphur Assimilation Is Essential for Virulence and Affects Iron Homeostasis of the Human-Pathogenic Mould Aspergillus fumigatus. Amich, J., Schafferer, L., Haas, H., Krappmann S. PLoS Pathog. 2013; 9(8):e1003573.
Manchester Fungal Infection Group
Division of Infection, Immunity and Respiratory Medicine
2.22 Core Technology Facility, 46 Grafton St.
Phone: +44 (0) 161 306 8164