Dr. Campbell Gourlay

Senior Lecturer in Cell Biology

Research Focus

Yeast Cell Biology

Scientific Activities

Campbell Gourlay began his career at The John Innes Centre in 1996 where he studied the genetic control of leaf development. Following this he began to work with budding yeast as a model eukaryote in the lab of Kathryn Ayscough, where he investigated the role of actin in the process of endocytosis. During this time he discovered a link between actin, the regulation of mitochondrial function and the control of ageing and apoptosis. This led to his involvement in the emerging field of yeast apoptosis, which has popularised the novel concept that unicellular organisms possess the ability to undergo programmed cell death as an altruistic act for the betterment of a population. In 2006 he was awarded a five year MRC Career Development Fellowship to establish his own lab within the Kent Fungal Group at the University of Kent where is now a senior lecturer in cell biology.

The Gourlay lab maintains a strong interest in the role that actin plays in the control of homeostatic mechanisms that contribute to healthy ageing. The lab also uses yeast as a model eukaryote to study a number of aspects of human disease. The group has also diversified to apply its understanding of yeast stress signalling processes and death to the fields of fungal pathogenesis and drug resistance. The group is also part of a multi-disciplinary team that investigates the formation, control and management of fungal biofilms on voice prosthesis in patients following total laryngectomy.

Significant Publications

arrant DJ, Stirpe M, Rowe M, Howard MJ, von der Haar T, Gourlay CW. Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism.  J Cell Sci. 2016 Nov 2. In Press PMID: 27807005

Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW. New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci. 2016 Nov 1;129(21):4118-4129.

Jane E. Leadsham, Geraldine Sanders, Samantha Giannaki, Emma Bastow, Rachael Hutton, Wesley R. Naeimi, Michael Breitenbach and Campbell W. Gourlay. Loss of Cytochrome c Oxidase promotes RAS dependent ROS production from the ER resident NADPH Oxidase, Yno1p, in yeast. Cell Metab. 2013 Aug 6;18(2):279-86.


Collaborators

Contact information

Kent Fungal Group
School of Biosciences
University of Kent
Canterbury
CT2 7NJ

Email: C.W.Gourlay@kent.ac.uk
Phone: +44 (0)1227 823535

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