Dr. Lily Novak Frazer

Lecturer in Medical Mycology, University of Manchester

Research Focus

Fungal molecular diagnostics, Antifungal resistance, Fungal biofilm development and metabolism

Scientific Activities

Lily Novak Frazer is a lecturer in Medical Mycology at the University of Manchester, based at the MAHSC at University Hospital of South Manchester, Wythenshawe Hospital and a Senior Molecular Scientist for the Mycology Reference Centre Manchester, also based at Wythenshawe Hospital.

She coordinates and lectures on the Masters in Medical Mycology programme as well as contributes to the Masters in Medical Microbiology and Virology programmes. She is also involved in extensive laboratory supervision of University of Manchester PhD students. In addition, she is a scientific consultant to the Mycology Reference Centre which is associated with the National Aspergillosis Centre. Her role is in the development of fungal molecular diagnostic tests. The latest development is the implementation of a service for monitoring resistance in the filamentous fungal, opportunistic pathogen Aspergillus fumigatus.

Her research interests include fungal molecular diagnostics in the context of identification and resistance testing as well as growth, development and metabolism and the effects of antifungal drugs on fungal and mixed community biofilms in the context of mucosal infections as well as chronic wounds.

She has published 22 peer-reviewed articles and reviews as well as two books or chapters on topics as varied as Candida albicans biofilm metabolism, mechanisms of yeast pre-mRNA splicing, morphogenetic development of basidiomycete fruiting bodies and protein profiling of filamentous ascomycete plant pathogens.

Significant Publications

Hayes, GE & Novak Frazer, L. (2016). Chronic Pulmonary Aspergillosis – where are we and where are we going? Journal of Fungi, 2(2): 18, doi:10.3390/jof2020018.6.

Nieminen, MT, Novak-Frazer, L, Rautemaa, V, Rajendran, R, Sorsa, T, Ramage, G, Bowyer, P & Rautemaa, R. (2014). A novel antifungal is active against Candida albicans biofilms and inhibits mutagenic acetaldehyde production in vitro. PlosOne 9(7): e101859. doi:10.1371/journal.pone.0101859.

Novak Frazer, L, Lovell, SC & O’Keefe, RT. (2009). Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome. Genetics 183:1-19.


Collaborators

Contact information

Education & Research Centre
UHSM Trust
Wythenshawe Hospital
Manchester
M23 9LT

Email: lily.novak-frazer@manchester.ac.uk
Phone: +44(0)1612914198

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