As a senior lecturer in the School of Biological Sciences at the University of Bristol, Dr. Bailey is heavily involved in both teaching and research in many aspects of fungal biology, plant pathology and biotechnology.
He also serves on the committee for the British Society for Plant Pathology
Dr. Bailey runs three different research themes centred on fungi:
Plant pathogenic fungi are common constraints on crop productivity so understanding their life cycles and infection processes is important for rational design of crop protection systems. Focusing on Zymoseptoria tritici, Dr. Bailey and colleagues are interested in diverse traits including asexual sporulation and its regulation, light perception and generation of small metabolites as possible toxins during disease processes.
Mushroom-forming fungi have often lagged behind other species in terms of research effort. Dr. Bailey and his team have spent considerable time in te development of transformation technologies, along with reporter-gene and silencing systems to allow genetic manipulation to be performed more reliably. These techniques have been applied to both model and non-model species, and cross over with the pathogenicity traits when applied either to pathogenic mushroom species such as Armillaria, or when the cultivated mushroom Agaricus bisporus is being attacked by other pathogenic species such as Lecanicillium fungicola.
Fungal secondary metabolites have a long history of exploitation, with Penicillin as the most obvious example, however genome sequence data has revealed that the metabolic potential of fungi is far wider than had previously been appreciated. Dr. Bailey and his team have considerable expertise in identification and characterisation of the genetic pathways underpinning secondary metabolite production in fungi, coupled with a synthetic biology approach to generate novel metabolites as lead compounds for development in the AgChem or Pharma sectors.
deMattos-Shipley et al. (2016) The good, the bad and the tasty; the many roles of mushrooms. Studies in Mycology: In press http://dx.doi.org/10.1016/j.simyco.2016.11.002
Heneghan et al (2016) Functional analysis of Agaricus bisporus serine proteinase 1 reveals roles in utilization of humic rich substrates and adaptation to the leaf-litter ecological niche. Environmental Microbiology: In press DOI: 10.1111/1462-2920.1335
Bailey et al (2016) Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production. Scientific Reports. 6, srep25202
School of Biological Sciences
University of Bristol
24 Tyndall Ave
Phone: +44 (0)117 3941171