Reader in Translational Biology
Eukaryotic chromosome replication & genome stability.
Research in MacNeill lab is focused on dissecting the molecular biology of eukaryotic chromosomal DNA replication and genome stability, primarily using two contrasting genetically-tractable model systems, the eukaryotic fission yeast Schizosaccharomyces pombe and the halophilic euryarchaeon Haloferax volcanii. In addition to this, we also study the replication machinery of the parasitic protozoan Trypanosoma brucei. We use a variety of methods to address questions of protein structure and function within the chromosome replication apparatus, including genetics and molecular biology, biochemistry and bioinformatics.
Salguero, I., Guarino, E., Shepherd, M., Deegan, T., Havens, C.G., MacNeill, S.A., Walter, J.C. and Kearsey, S.E. (2012) Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA). Curr. Biol., 22, 720-726.
Kim, J., Robertson, K., Mylonas, K.J.L., Gray, F.C., Charapitsa, I. and MacNeill, S.A. (2005) Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully-functional RFC in fission yeast. Nucl. Acids Res., 33, 4078-4089.
Tanaka, H., Ryu, G.-H., Seo, Y.-S., and MacNeill, S.A. (2004) Genetic analysis of lagging strand DNA synthesis in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta. Nucl. Acid Res.32: 6367-6377.
Biomedical Sciences Research Complex
School of Biology
University of St Andrews
Phone: +44 (0)1334 467 268